The compound tetracaine hydrochloride mucilage plays a good role in the field of medicine.
Gastroscopy is an effective method for the clinical diagnosis of upper gastrointestinal diseases. However, due to the foamy mucus in the esophagus and stomach, and the patient uncomfortable swallowing the newly added foamy mucus during the examination, the visual field is not clear, which affects the observation and operation. In order to improve the accuracy of gastroscopy and reduce the suffering of patients, medical workers have conducted many studies on the use of local anesthetics and antifoaming agents in gastroscopy. It has been clinically proven that a multifunctional preparation for gastroscopy that combines local anesthetics and antifoaming agents is more effective than local anesthetics or antifoaming agents alone. Relevant units have developed a compound tetracaine hydrochloride mucilage that integrates local anesthesia, defoaming, and lubrication. The mucous membrane of the throat is anesthetized quickly, the effect is accurate, and the adverse reactions are mild, but some patients have poor defoaming performance, which affects endoscopy. Observed. Although dimethicone in its formulation has preliminary defoaming properties, its dispersing properties are poor, and it must be uniformly dispersed in order to exert a good defoaming effect. Combined with clinical practice, the formula was screened with defoaming rate as an index, the preparation process of compound tetracaine hydrochloride mucilage was optimized, its defoaming performance was improved, and it also provided the reference for the development of its new dosage form.
1. Preparation of compound tetracaine hydrochloride mucilage
Take sodium carboxymethyl cellulose, add an appropriate amount of hot purified water, swell naturally, leave it overnight to completely dissolve, add dimethicone, glycerin, and polysorbate 80, stir evenly, heat to about 80 degree , use high shear Mixing emulsifier for 10 min to complete the emulsification; add tetracaine hydrochloride and citric acid, add purified water to dissolve, combine with the above solution, and stir well; add ethylparaben dissolved in an appropriate amount of ethanol, add purified water to 100 ml, stir well, and that's it.
2. Determination of defoaming rate
The defoaming properties of the drug were determined by the graduated cylinder method. Under the conditions of room temperature and normal pressure, take a 100 ml graduated cylinder, add 20 ml of foaming liquid (0.031 moL/L octyl benzene polyol aqueous solution), plug the graduated cylinder with a cork with a hole, and shake up and down (oscillation amplitude 30-40 cm, shaking rate 50-70 times/min), make the foam volume reach the 60 ml mark, add 0.2 ml of the test solution (such as defoamer) along the tube wall with a plastic tip dropper, and record after 30 min. Foam volume (V). The smaller the remaining foam volume, the greater the defoaming rate, indicating that the defoaming performance of the compound tetracaine hydrochloride mucilage is better. Defoaming rate (v, ml/min) = (60 - V) / 30.
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